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Seit Beginn dieses Jahres steht in unserer Praxis der Time-Lapse-Inkubator Geri der Firma Merck im Rahmen einer IVF- und ICSI-Behandlung zur Verfügung.

Der Time-Lapse Inkubator Geri hat wesentliche Vorteile zum herkömmlichen Inkubator. Er ermöglicht eine völlig ungestörte Embryonalentwicklung mit äußerst stabilen Kulturbedingungen bei einer kontinuierlichen Überwachung des Embryowachstums. Dies ermöglicht die Auswahl der besten Embryonen wodurch günstigere Voraussetzungen für den Eintritt einer Schwangerschaft bestehen.

Wenn Sie mehr über das Time-Lapse-System erfahren möchten, sprechen Sie uns an oder vereinbaren Sie einen Termin bei Ihrem Arzt/Ihrer Ärztin.

Crispr: Diese Versuche haben mit Designerbabys nichts zu tun

Der Skandal um Chinas Designerbabys bringt Crispr-Forscher weltweit in Verruf. Dabei arbeiten die wenigsten an Embryonen. Woran dann? Wir haben sieben von ihnen gefragt.

Es war einer der größten Science-Coups dieses Jahrzehnts: Die Entdeckung der Genschere Crispr/Cas9, einsetzbar von der Medizin bis zur Landwirtschaft. Mit der Methode, abgeguckt von Bakterien, lässt sich Erbgut ausschneiden, verändern und wieder einbauen. Egal, ob es um DNA von Pflanzen, Tieren oder Menschen geht. Und das funktioniert so günstig, präzise und schnell wie keine andere Gentechnik. Deshalb arbeiten Labors weltweit mit Crispr.

Trotzdem wissen alle, die Crispr nutzen: Auf diese Art in Erbgut einzugreifen, ist riskant, die Technik längst nicht ausgereift genug, als dass man sie an Menschen testen sollte – selbst wenn man das ethisch – etwa um sonst tödliche Krankheiten damit zu heilen – für vertretbar hielte. He Jiankui aus Chinahat es, wie er behauptet, trotzdem gemacht. Vor wenigen Tagen erfuhr die Welt von den wohl ersten Crispr-Babys, erzeugt durch künstliche Befruchtung, nachdem ihr Erbgut im Labor mit Crispr immun gegen HIV gemacht wurde. Angeblich. Entsetzt, besorgt und mit heftiger Kritik haben Fachkollegen weltweit auf diesen Alleingang reagiert. Auch weil Jiankui mit seinem Tabubruch ihrer aller Arbeit in Verruf gebracht hat.

Der Skandal erweckt den Anschein, Crispr-Nutzer würden vor allem am Menschen herumschnipseln. Dabei sind Experimente an Embryonen die Ausnahme. Nie zuvor wurden sie überhaupt einer Frau eingepflanzt. Viel häufiger geht es um Nutzpflanzen, um Medikamente oder Organismen für die Landwirtschaft. Wir haben sieben Forscherinnen und Wissenschaftler gefragt, warum sie Crispr nutzen, was sie erforschen und wie sie über die Risiken der Genschere denken.

(..) Artikel auf Zeit Online lesen

Kinderwunsch – Wenn zwei Frauen sich gemeinsam ein Kind wünschen

Den Wunsch nach einem eigenen Kind haben viele Frauen, unabhängig davon, ob sie mit einem Mann oder einer Frau zusammenleben. Die meisten Reproduktionsmediziner haben sich inzwischen auch auf die Bedürfnisse lesbischer Paare eingestellt.

Um ein gängiges Vorurteil gleich zu Beginn auszuräumen: Die fehlende Vaterfigur sei nicht das Problem, betont Dr. med. Matthias Bloechle vom Kinderwunschzentrum an der Gedächtniskirche in Berlin: „Auch in Hetero-Beziehungen ist es häufig so, dass der Vater vielleicht aufgrund seiner Berufstätigkeit nur selten oder gar nicht anwesend ist. Das Gleiche gilt nach einer Trennung der Eltern. Eine männliche Orientierung für das Kind können auch Freunde des lesbischen Paares, deren Brüder, Väter oder Cousins bieten.“ Bisher hätten internationale Studien über Kinder in reinen Frauenhaushalten keine psychosozialen Auffälligkeiten nachgewiesen. Festgestellt wurde lediglich, dass diese Kinder als Jugendliche weniger Alkohol konsumieren als andere.

Samenspende von Bekannten oder von der Samenbank?

Das größte „Problem“ für lesbische Paare sei, dass sie innerhalb der Partnerschaft keine eigene Samenquelle haben. Daher müssten sich die Frauen vorher überlegen, ob sie einen Bekannten bitten, eine Samenspende zur Verfügung zu stellen, oder ob sie eine anonyme Spende von einer Samenbank nutzen möchten. „Der überwiegende Teil meiner Klientinnen wählt die Samenbank“, erklärt Dr. Bloechle. „Nur 10-15 Prozent entscheiden sich für die private Spende eines Bekannten. Wer letzteren Weg wählt, sollte vorher mit dem Spender besprechen, ob er nach der Geburt des Kindes eine Familienbeteiligung anstrebt und ob diese gewünscht ist. Ein anonymer Samenspender hat den Vorteil, dass er später nicht mitdiskutiert, ob das Kind nun Französisch oder Latein als Fremdsprache wählen soll.“

Wichtig zu wissen: Vom Gesetz her kann jeder Samenspender das Recht einklagen, sein Kind regelmäßig zu sehen. „Und auch viele Kinder hegen im Laufe ihrer Entwicklung den Wunsch, etwas über ihren Erzeuger zu erfahren“, weiß Reproduktionsmediziner Bloechle. „Zur Identitätsfindung reicht häufig schon ein Foto, denn die Kinder möchten sehen, wie ihr Erzeuger aussieht. Einige möchten auch persönlichen Kontakt aufnehmen, um etwas mehr über ihren biologischen Vater in Erfahrung zu bringen.“

Legale Kinderwunsch-Erfüllung nach medizinischen Standards

Die Richtlinien zur Durchführung einer Insemination, einer künstlichen Befruchtung, wurden in Deutschland mittlerweile überarbeitet. So ist es den Ärzten heutzutage erlaubt, die Insemination auch bei unverheirateten Frauen durchzuführen. „Es besteht keinerlei Notwendigkeit mehr, sich allein zum Zweck einer Kindszeugung mit Unbekannten in schummrigen Bars oder Hotelzimmern zu verabreden, womöglich noch gegen Bezahlung“, sagt Dr. Bloechle. „Wir bieten bei uns im Kinderwunschzentrum eine saubere medizinische Beratung und Betreuung. Auch der eigentliche Befruchtungsvorgang ist unproblematisch, sofern die Mutter in spe gesund ist: Wir überprüfen per Ultraschall, wann der Eisprung erfolgt. Die Samenspende wird dann mit einem kleinen Plastikkatheter in die Gebärmutter eingeführt. Dieser Vorgang ist nicht aufwendiger und unangenehmer als ein Krebsabstrich bei einer Routinekontrolle.“

Bei gynäkologischen Besonderheiten, etwa wenn ein Eileiterverschluss oder eine Endometriose diagnostiziert wurden, rät der Reproduktionsmediziner in der Regel zu einer In-Vitro-Befruchtung. Dazu werden während einer kurzen Narkose Eizellen entnommen und außerhalb des Körpers befruchtet. Ein bis zwei dieser befruchteten Eizellen werden dann in die Gebärmutter eingesetzt, bei älteren Patientinnen auch mehr, da die Fruchtbarkeit ab dem 30. Lebensjahr deutlich abnimmt.

Jede Schwangerschaft ist ein kleines Wunder

„Wie bei einer natürlichen Zeugung ist auch bei einer künstlichen Befruchtung nicht garantiert, dass es beim ersten Mal klappt“, so Dr. Bloechle. Nervliche Belastungen, Stress oder Konflikte bei der Arbeit wirken sich häufig auf die Empfängnisbereitschaft aus. Grundsätzlich könne man die Befruchtung aber beliebig häufig wiederholen, so der Kinderwunschexperte. Die Kosten für die künstliche Befruchtung müssen lesbische Paare selbst tragen. Eine Spende von der Samenbank kostet zwischen 500 und 1000 Euro, die Insemination selbst etwa 500 Euro. Für den Fall, dass eine In-Vitro-Befruchtung außerhalb des Körpers notwendig ist, liegen die Kosten bei 4000 bis 5000 Euro. Aber am guten Ende denkt wohl niemand mehr über vergangene Kosten nach. Denn egal ob Single-Mutter, Mann und Frau oder lesbisches Paar – wenn sie ihr Wunschkind endlich in den Armen halten, wird alles andere zur Nebensache.

von Susanne Amrhein, PRIMO MEDICO

16. Internationale Konferenz der Präimplantationsgenetik


Vom 26.-29.03.2017 fand in Valencia die 16. Internationale Konferenz über Präimplantationsgenetik statt.

Zahlreiche internationale Arbeitsgruppen aus Europa, Amerika und Asien präsentierten ihre Ergebnisse zur genetischen Diagnostik mit den aktuellen Untersuchungstechniken an Eizellen und Embryonen.

Mit dem Next Generation Sequencing ist es möglich genetische Fehler an Eizellen und Embryonen zu erkennen und die fehlerbehafteten Embryonen von einem Transfer auszuschließen.

Die beiden Abbildungen mit Daten von Gary Harton, einem amerikanischen Wissenschaftler, belegen eindrucksvoll, daß Embryonen, welche nach PGS als genetisch gesund eingestuft wurden, sich auch bei Frauen über 40 Jahren genauso gut und häufig wie bei jüngeren Frauen  einnisten und daß die Fehlgeburtenrate durch einen genetische Untersuchung (PGS) deutlich gesenkt werden kann.

In unserem Hause erzielen wir nach Transfer von genetisch getesteten Eizellen oder Embryonen eine Schwangerschaftsrate von 65-70% bei Transfer von nur einem einzelnen chromosomal gesunden Embryo!

Das bedeutet: eine sehr hohe Erfolgsrate ohne Zwillingsrisiko! – und belegt die Bedeutung einer regelrechten Chromosomenausstattung des Embryos für den Eintritt einer Schwangerschaft.

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